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Corticolimbic Degeneration and Treatment of Dementia

PI: Csernansky

Summary:
To determine whether drugs currently used to treat Alzheimer disease alter the underlying disease process, as assessed using markers of brain structure and cognition in dementia patients and markers of amyloid deposition and neurodegeneration in APP-transgenic mice.

Papers:

• Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly.
  Csernansky JG, Wang L, Swank J, Miller JP, Gado M, McKeel D, Miller MI, Morris JC
  Neuroimage 2005; 25(3): 783-92
  PMID: 15808979