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HippoPCI: Hippocampal Predictors of Cognitive Impairment in Breast Cancer Patients

PI: Wang

Summary:
This is a longitudinal magnetic resonance imaging (MRI) study where we identify predictors and mechanisms of cognitive impairment in breast cancer patients receiving hormonal treatment by using structural and functional assessments that are sensitive to the integrity of the hippocampal-cortical circuitry.

Papers:

• Reduced Prefrontal Activation During Working and Long-Term Memory Tasks and Impaired Patient-Reported Cognition Among Cancer Survivors Post-chemotherapy Compared With Healthy Controls..
  Wang L*, Apple AC*, Schroeder MP, Ryals AJ, Voss JL, Gitelman D, Sweet JJ, Butt Z, Cella D, Wagner LI,
  Cancer 2015; 21
  View Article
  
• Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns.
  Apple, A., Ryals, A., Alpert, K., Wagner, L., Cella, D., Penedo, F., Voss, J., Wang, L.
  NeuroImage: Clinical 2017; 14: 685-691
  PMID: 28377882
  
• Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy.
  Apple AC, Schroeder MP, Ryals AJ, Wagner LI, Cella D, Shih PA, Reilly J, Penedo FJ, Voss JL, Wang L
  NeuroImage Clinical 2018; 20: 110-8
  View Article
  

Presentations:

• Hippocampal deformation in Breast Cancer Patients with Self Reported Cognitive Concerns
  Apple A.C., Ryals A.J., Voss J.L., Wang L. INS (Denver, CO -- February 2015)
  Download Presentation
  

Funding:

• 1R01 NR014182: HippoPCI Hippocampal Predictors of Cognitive Impairment in Breast Cancer Patients (PI: Wang) - Post-surgery adjuvant therapy produces changes in cognitive function in up 10-70% of women with breast cancer. To date, no investigation has assessed the neural correlates of adjuvant hormonal therapy, nor have any studies determined how to identify individuals at risk for treatment-related cognitive impairment. We propose to use longitudinal magnetic resonance imaging (MRI) to identify predictors and mechanisms of cognitive impairment in breast cancer patients receiving hormonal treatment. (09/26/2012 - 06/30/2018).

Details:
Post-surgery adjuvant therapy produces changes in cognitive function in up to 70% women with breast cancer. Our recent work demonstrates that breast cancer patients receiving adjuvant hormonal treatment also exhibit a decline in cognition three months post treatment, providing new evidence that MCI also arises from hormonal therapy. To date, no investigation has assessed the neural correlates of adjuvant hormonal therapy, nor have any studies determined how to identify individuals at risk for treatment-related cognitive impairment. We propose to use longitudinal magnetic resonance imaging (MRI) to identify predictors and mechanisms of cognitive impairment in breast cancer patients receiving hormonal treatment. We will achieve this by using structural and functional assessments that are sensitive to the integrity of the hippocampal-cortical circuitry. Our central hypothesis is that measures of the hippocampal-cortical circuitry can be used to predict cognitive decline, and that the trajectories of specific domains of cognitive performance in patients receiving adjuvant therapy may be related to trajectories of specific hippocampal-cortical circuitry components.