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Acquisition and consolidation of trace eyeblink conditioning in rabbits using prestimulus theta activity and manganese-enhanced MRI

PI: Disterhoft, Wang

What does the development of memory formation look like and what is the nature of the interactions that exist between the hippocampus and cortical regions to enable information storage? Does the rapid acquisition of a memory encompass the same neural network as one that is acquired at a normal pace? The acquisition of memory is initially dependent on the hippocampus but the long-term storage of memory, termed consolidation, likely resides in the neocortex in a single area or network of regions. Because of the likely neural distribution of a consolidated memory in the neocortex, it is favorable to employ methods that simultaneously examine the entire brain. The goal of the proposed research is to determine how the gradual process of consolidation is incorporated in the brain and how factors involved in the acquisition phase influence the consolidated neural network.


  • T32 NS047987-05 NINDS: Training Program in the Neuroscience of Human Cognition (PI: Paller. Predoctoral student: Matthew Schroeder) - The project for this program focuses on identifying the neural regions responsible to acquisition and consolidation of a conditioned task in rabbits using manganese-enhanced MRI. (09/20/2011 - 09/19/2013).